Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 194, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111168
Keywords
Alginate; Microspheres; Hemostasis; Antibacterial; Biocompatibility
Funding
- National Natural Science Foundation of China [81803339]
- Natural Science Foundation of Zhejiang Province [LY18H300008]
- Zhejiang Provincial Top Key Discipline of Biology
- 521 Talent Cultivation Plan of Zhejiang Sci-Tech University
- Animal Experimental Center of Hangzhou Normal University
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It is important to develop effective, biocompatible, easily stored and affordable hemostats for controlling bleeding and preventing infection in prehospital trauma. In this study, we synthesized a series of alginate-based composite microspheres coated by different amounts of berberine (SCC-1B, SCC-5B and SCC-10B), which were further characterized using scanning electron microscopy (SEM), viscometer, particle analyzer and Fourier transform infrared (FT-IR) spectroscopy. The in vitro and vivo results demonstrated that compared to control group (SCC, Composite polysaccharide microspheres without berberine, and CMPHP, Commercial hemostatic agent), SCC-10B with proper content berberine (7%), not only exhibited inherent excellent antibacterial activity, but also enhanced hemostatic effect by increasing adhesion and aggregation of blood cells, which could be considered as synergistic effects. More importantly, through inserting berberine into the cross-linked network, biodegradability and biocompatibility of SCC-10B were also improved. Taken together, SCC-10B could be a candidate for emergency hemostatic and antibacterial treatment in prehospital trauma.
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