Journal
CLINICS IN DERMATOLOGY
Volume 39, Issue 2, Pages 176-182Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2020.10.015
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Circumscribed palmoplantar hypokeratosis is a rare acquired dermatosis mainly affecting middle-aged or elderly women, presenting clinically with sharply limited, annular erythematous plaques. Despite its characteristic clinical and microscopic features, the pathogenesis and treatment of the disease remain unclear.
Circumscribed palmoplantar hypokeratosis (CPH) is a rare acquired dermatosis first described in 2002. It affects mostly the thenar or hypothenar eminences of the palm of middle-aged or elderly women and manifests clinically with sharply limited, annular erythematous plaques with a depressed surface, rimmed by a slightly raised, keratotic border. Microscopically, circumscribed palmoplantar hypokeratosis shows a sharp decrease of the horny layer thickness, with few, if any, associated changes (parakeratosis, dermal inflammation). Despite a characteristic clinical and microscopic aspect, the disease remains poorly known, as does its pathogenesis, even if several hypotheses have been proposed (clonal epidermal malformation, disorder of epidermal differentiation/keratinization and/or desquamation, human papillomavirus- or trauma-induced disease). Several therapies have been proposed with varying results, the best ones achieved with surgical excision; however, because the disease is benign, intervention is optional. (C) 2020 Elsevier Inc. All rights reserved.
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