Related references
Note: Only part of the references are listed.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
Manli Wang et al.
CELL RESEARCH (2020)
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
Calvin J. Gordon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Emmie de Wit et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
Timothy P. Sheahan et al.
NATURE COMMUNICATIONS (2020)
Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit
Duxin Sun
AAPS JOURNAL (2020)
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann et al.
CELL (2020)
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
Calvin J. Gordon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
Shutoku Matsuyama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Yan Gao et al.
SCIENCE (2020)
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial
Yeming Wang et al.
LANCET (2020)
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
Jason D. Goldman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Remdesivir for the Treatment of Covid-19-Final Report
John H. Beigel et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19
B. Cao et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Compassionate Use of Remdesivir for Patients with Severe Covid-19
J. Grein et al.
NEW ENGLAND JOURNAL OF MEDICINE (2020)
Remdesivir: Review of Pharmacology, Pre-clinical Data, and Emerging Clinical Experience for COVID-19
Sarah C. J. Jorgensen et al.
PHARMACOTHERAPY (2020)
Coronavirus Disease 2019-COVID-19
Kuldeep Dhama et al.
CLINICAL MICROBIOLOGY REVIEWS (2020)
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon et al.
ANTIVIRAL RESEARCH (2020)
Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro
Ka-Tim Choy et al.
ANTIVIRAL RESEARCH (2020)
Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID-19, in Healthy Subjects
Rita Humeniuk et al.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)
Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection A Randomized Clinical Trial
Mayla Gabriela Silva Borba et al.
JAMA NETWORK OPEN (2020)
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
Natacha S. Ogando et al.
JOURNAL OF GENERAL VIROLOGY (2020)
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Brandi N. Williamson et al.
NATURE (2020)
Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post-treatment hospitalisation status
Spinello Antinori et al.
PHARMACOLOGICAL RESEARCH (2020)
Isolation, Sequence, Infectivity and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2
Arinjay Banerjee et al.
EMERGING INFECTIOUS DISEASES (2020)
The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold
Mary K. Yates et al.
ANTIVIRAL RESEARCH (2019)
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Egor P. Tchesnokov et al.
VIRUSES-BASEL (2019)
Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
Robert N. Kirchdoerfer et al.
NATURE COMMUNICATIONS (2019)
Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
Ariane J. Brown et al.
ANTIVIRAL RESEARCH (2019)
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics
Sabue Mulangu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold
Katherine L. Seley-Radtke et al.
ANTIVIRAL RESEARCH (2018)
Testing therapeutics in cell-based assays: Factors that influence the apparent potency of drugs
Elena Postnikova et al.
PLOS ONE (2018)
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Maria L. Agostini et al.
MBIO (2018)
A mouse model for MERS coronavirus-induced acute respiratory distress syndrome
Adam S. Cockrell et al.
NATURE MICROBIOLOGY (2017)
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Timothy P. Sheahan et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses
Michael K. Lo et al.
SCIENTIFIC REPORTS (2017)
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren et al.
NATURE (2016)
A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection
Richard T. Davey et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug
Joy Y. Feng et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Common and unique features of viral RNA-dependent polymerases
Aartjan J. W. te Velthuis
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
Discovery of the First C-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients
Aesop Cho et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus
Jerome Deval et al.
CURRENT OPINION IN VIROLOGY (2014)
Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children
Tom Jefferson et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2014)
Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
Lars Petter Jordheim et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
Aesop Cho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Species difference of esterase expression and hydrolase activity in plasma
Fatma Goksin Bahar et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
A 40-Year Journey in Search of Selective Antiviral Chemotherapy
Erik De Clercq
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)
Cell-based assays to identify inhibitors of viral disease
Neil Green et al.
EXPERT OPINION ON DRUG DISCOVERY (2008)
Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase
Egor P. Tchesnokov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Pre-steady-state kinetic studies establish entecavir 5′-triphosphate as a substrate for HIV-1 reverse transcriptase
Robert A. Domaoal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The mechanism of action of β-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidme involves a second metabolic pathway leading to β-D-2'-deoxy-2-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
Eisuke Murakami et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Application of phosphoramidate ProTide technology significantly improves antiviral potency of carbocyclic adenosine derivatives
Christopher McGuigan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
SARS-associated coronavirus replication in cell lines
M Kaye et al.
EMERGING INFECTIOUS DISEASES (2006)
Antiviral acyclic nucleoside phosphonates structure activity studies
Antonin Holy
ANTIVIRAL RESEARCH (2006)
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication
EC Mossel et al.
JOURNAL OF VIROLOGY (2005)
Share Paper
