4.7 Article

Severe Acute Respiratory Syndrome Coronavirus 2 RNA in Plasma Is Associated With Intensive Care Unit Admission and Mortality in Patients Hospitalized With Coronavirus Disease 2019

Journal

CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 3, Pages E799-E802

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1338

Keywords

SARS-CoV-2; COVID-19; RNAemia; viral load; antibodies

Funding

  1. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo

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Detection of severe acute respiratory syndrome coronavirus 2 RNA in the circulation may be associated with disease severity and poor outcomes in patients hospitalized with coronavirus disease 2019.
The clinical significance of severe acute respiratory syndrome coronavirus 2 RNA in the circulation is unknown. In this prospective cohort study, we detected viral RNA in the plasma of 58 of 123 (47%) patients hospitalized with coronavirus disease 2019. RNA was detected more frequently, and levels were higher, in patients who were admitted to the intensive care unit and/or died.

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