Journal
CLINICA CHIMICA ACTA
Volume 508, Issue -, Pages 110-114Publisher
ELSEVIER
DOI: 10.1016/j.cca.2020.05.019
Keywords
COVID-19; Lymphocyte subsets; CD3(+) T cells; CD4(+) T cells; CD8(+) T cells
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Funding
- National Natural Science Foundation of China
- National Mega Project on Major Infectious Disease Prevention
- Open Research Program of the State Key Laboratory of Virology of China
- Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai
- Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai
- Postdoctoral Sustentation Fund of Shanghai Gongli Hospital, Secondary Military Medical University
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Background: We observe changes of the main lymphocyte subsets (CD16(+)CD56.CD19, CD3, CD4, and CD8) in COVID-19-infected patients and explore whether the changes are associated with disease severity. Methods: One-hundred and fifty-four cases of COVID-19-infected patients were selected and divided into 3 groups (moderate group, severe group and critical group). The flow cytometry assay was performed to examine the numbers of lymphocyte subsets. Results: CD3(+), CD4(+) and CD8(+) T lymphocyte subsets were decreased in COVID-19-infected patients. Compared with the moderate group and the sever group, CD3(+), CD4(+) and CD8(+) T cells in the critical group decreased greatly (P < 0.001, P = 0.005 or P = 0.001). Conclusions: Reduced CD3(+), CD4(+), CD8(+) T lymphocyte counts may reflect the severity of the COVID-19. Monitoring T cell changes has important implications for the diagnosis and treatment of severe patients who may become critically ill.
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