Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 37, Issue 9-10, Pages 1452-1456Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07420528.2020.1803901
Keywords
Circadian adaptation; circadian misalignment; IL-6 diurnal pattern; immune response; laboratory study; physiological stressor response; shift work; single nucleotide polymorphism; sleep loss
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Funding
- U.S. Army Medical Research and Development Command [W81XWH-18-1-0100]
- Federal Motor Carrier Safety Administration [DTMC75-07-D-00006]
- Sleep Research Society Foundation
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TheBDNFgene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.
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