Journal
CHRONOBIOLOGY INTERNATIONAL
Volume 37, Issue 9-10, Pages 1457-1460Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07420528.2020.1804925
Keywords
Sustained attention; psychomotor vigilance test (PVT); cognitive impairment; sleep loss; single nucleotide polymorphism; dopamine; striatum
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Funding
- Congressionally Directed Medical Research Programs [W81XWH-16-1-0319]
- U.S. Army Medical Research and Development Command [W81XWH-18-1-0100]
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Total sleep deprivation (TSD) and time-on-task (TOT), especially in combination, increase cognitive instability and cause performance impairment. There are large inter-individual differences in TSD and TOT effects which, in part, have a genetic basis. Here, we show that the dopamine receptor D(2)C957T genetic polymorphism predicts the magnitude of the TOT effect on a psychomotor vigilance test (PVT) during 38 h of TSD. This finding indicates that dopamine availability in the striatum, where the dopamine receptor D(2)is most prevalent, influences the TOT effect, suggesting a role for dopaminergic pathways in sustained attention deficits during sleep loss.
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