Recent Advances of Trifluoromethoxylation Reactions Using TFMS and TFBO

The OCF3 group has good metabolic stability, suitable lipophilicity and special electrical properties, which can modify the properties of drugs and material molecules. In recent years, trifluoromethoxy compounds have received more and more attention. Both new reagents and new trifluoromethoxylation strategies got a breakthrough. Our group has been committed to the development of trifluoromethoxylation reagents and methods. This account focuses on describing various trifluoromethoxylation reactions with trifluoromethyl sulfonates (TFMS) and (E)-O-trifluoromethyl-benzaldoximes (TFBO) developed by our group. What is the most favorite and original chemistry developed in your research group? Trifluoromethyl sulfonates (TFMS) and various trifluoromethoxylation reactions. How do you get into this specific field? Could you please share some experiences with our readers? I got into fluorine chemistry during my postdoctoral period. The importance of fluorine chemistry in medical and material fields inspired me to put my heart and soul into fluorine chemistry. The criterion I always persist in is Keep arming yourself before opportunities come. How do you supervise your students? Guide and inspire students in the research direction. Do not kill students' ideas. Let them do what they want. What is the most important personality for scientific research? Perseverance, thinking, learning and diligence. What's your hobbies? I like sports, especially playing ping-pong. How do you keep balance between research and family? I spend every weekend with my family. And the support and understanding from my family made me more motivated to throw myself into work.

Automated summary

The article highlights the characteristics of trifluoromethoxy compounds and their applications in the fields of medicine and materials, focusing on various trifluoromethoxylation reactions using trifluoromethyl sulfonates and trifluoromethyl benzaldoximes developed by the research team.