Journal
CHINESE CHEMICAL LETTERS
Volume 32, Issue 2, Pages 660-667Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.08.027
Keywords
N-Heterocyclic carbene; Radical; Photocatalysis; Organocatalysis; SET
Categories
Funding
- National Natural Science Foundation of China [21672216, 21831008]
- Beijing National Laboratory for Molecular Sciences [BNLMS-CXXM-202003]
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N-heterocyclic carbene (NHC)-catalyzed reactions involving two-electron and radical pathways have been well-established, with the former more developed than the latter in terms of reaction types and enantioselectivity. In the past decade, several elegant NHC-catalyzed radical reactions have been developed, including oxidation of aldehydes, reductive coupling reactions, and reactions via radical homoenolates.
The N-heterocyclic carbene (NHC)-catalyzed reactions involving two-electron reaction pathway have been well-established. However, the development of NHC-catalyzed radical reactions is still in its infancy in terms of reaction types and enantioselectivity. In the past decade, several elegant NHC-catalyzed radical reactions have been developed, including NHC-catalyzed oxidation of aldehydes to esters, reductive coupling reactions using Breslow intermediate as SET reductant and NHC-catalyzed reactions via radical homoenolates, dienoaltes and trienolates. This review summarizes the recent advances in NHC-catalyzed reactions involving radical intermediates. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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