Conducting polymer engineered covalent organic framework as a novel electrochemical amplifier for ultrasensitive detection of acetaminophen

Two-dimensional covalent organic framework (COF) has distinctive properties that offer potential opportunities for developing advanced electrode materials. In this work, a core-shell material composed of TAPB-DMTP-COF (TAPB, 1,3,5-tris(4-aminophenyl)benzene; DMTP, 2,5-dimethoxyterephaldehyde) core and conducting polymer shell, TAPB-DMTP-COF@PANI, was synthesized solvothermally using a polymerization method. The structural characteristics of the prepared composite were revealed by X-ray diffraction patterns (XRD), fourier transform infrared spectra (FTIR), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM). The electrochemical analyses were verified by subsequent monitoring of trace levels of acetaminophen. This resultant composite not only facilitated acetaminophen to interact with absorption sites by pi-pi stacking effect and hydrogen bonding but also overcame the poor conductivity of COF. Under the optimal conditions, a low limit of detection of 0.032 mu mol/L and wide linear range of 0.10-500 mu mol/L were obtained. The electrochemical platform was almost unaffected by other interfering substances, and successfully applied for the practical detection of acetaminophen in commercial tablet, human blood serum and urine. The enhanced performance makes this COF based core-shell composite a promising material in electrochemical sensor. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

A core-shell material composed of TAPB-DMTP-COF core and conducting polymer shell, TAPB-DMTP-COF@PANI, was successfully synthesized and showed promising performance in electrochemical sensor applications for detecting acetaminophen, indicating its potential for practical use.