Journal
CHINESE CHEMICAL LETTERS
Volume 32, Issue 3, Pages 1010-1016Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.09.010
Keywords
Photothermal therapy; RNAi; RNA interference; siRNA; Small interfering RNA; Gold nanoparticle; Carbon nanoparticle
Categories
Funding
- Hunan Provincial Natural Science Foundation of China [2018JJ1019]
- HuXiang Young Talent Program [2018RS3094]
- National Natural Science Foundation of China [31871003]
- Beijing Institute of Technology Research Fund Program for Young Scholars
- Fundamental Research Funds for the Central Universities [2018CX01023]
- Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology
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Photothermal therapy (PTT) is a new treatment technique that has attracted worldwide attention in cancer treatment due to its excellent absorption ability, easy regulation, and biodegradability. The synergistic therapy of photothermal and RNA interfering (RNAi) has recently become a hot research topic, showing potential in enhancing the therapeutic effect against tumors.
As a new treatment technique, photothermal therapy (PTT) has aroused worldwide attention in cancer treatment, mainly due to its excellent absorption ability, easy regulation, and biodegradability. Photothermal conversion materials with enhanced permeability and retention effect can be targeted easily to tumor tissue. They can accumulate efficiently to tumor tissues and allow normal tissues and organs not to be affected by temperature, thus significantly helping to reduce the systemic toxicity and improve the antitumor effect. However, PTT alone often suffers from therapeutic resistance and reduced therapeutic efficacy, due to photothermal nanomaterial-mediated fundamental cellular defense mechanism of heat shock response, which could be inhibited by small interfering RNA (siRNA). Nevertheless, photothermal conversion materials as an excellent siRNA delivery carrier may considerably enhance the delivery efficiency of siRNA. Therefore, photothermal and RNA interfering (RNAi) synergistic therapy has recently aroused extensive attention in tumor treatment. In this review, we mainly summarize the recent advances of photothermal and RNAi synergistic therapy, including some synergistic therapeutic nanoplatforms of inorganic and organic photothermal materials and other combined therapies such as combining with small molecular antitumor agents or PDT/imaging. The combination of various treatment techniques may considerably improve the synergistic therapeutic effect of PTT and RNAi in the treatment of cancers. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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