4.5 Article

Spermine Derivatives of Indole-3-carboxylic Acid, Indole-3-acetic Acid and Indole-3-acrylic Acid as Gram-Negative Antibiotic Adjuvants

Journal

CHEMMEDCHEM
Volume 16, Issue 3, Pages 513-523

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202000359

Keywords

Indoles; polyamines; adjuvants; enhancers; antibiotics

Funding

  1. Auckland Medical Research Foundation [1116001]
  2. Wellcome Trust (UK)
  3. University of Queensland (Australia)

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The discovery of new antibiotic adjuvants is crucial for combating antimicrobial resistance. Some newly discovered compounds show good antibiotic adjuvant activities with lower cytotoxic and haemolytic properties, indicating their potential for further development as treatment options.
The discovery of new antibiotic adjuvants is an attractive option for overcoming antimicrobial resistance. We have previously reported the discovery of a bis-6-bromoindolglyoxylamide derivative of spermine as being able to enhance the action of antibiotics against Gram-negative bacteria but suffers from being cytotoxic and red-blood cell haemolytic. A series of analogues was prepared exploring variation of the indolglyoxylamide unit, to include indole-3-acrylic, indole-3-acetic and indole-3-carboxylate units, and evaluated for antibiotic enhancing properties against a range of Gram-negative bacteria, and for intrinsic antimicrobial, cytotoxic and haemolytic properties. Two spermine derivatives, bearing 5-bromo-indole-3-acetic acid (17) and 5-methoxy-indole-3-acrylic acid (14) end groups were found to exhibit good to moderate antibiotic adjuvant activities for doxycycline towards the Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae, but with more modest intrinsic antimicrobial activity and greatly reduced cytotoxic and haemolytic properties. The mechanism of action of the latter derivative identified its ability to disrupt the outer membranes of bacteria and to inhibit the AcrAB-TolC efflux pump directly or by inhibiting the proton gradient.

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