Journal
CHEMMEDCHEM
Volume 16, Issue 1, Pages 124-133Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202000626
Keywords
Biofilm; Candida auris; Cytotoxicity; Drug resistance; Hemolysis; Monohydrazones
Categories
Funding
- College of Pharmacy at the University of Kentucky
- NIH [R01 CA172379, P20GM130456]
- Office of the Dean of the College of Medicine
- Markey Cancer Center
- Center for Pharmaceutical Research and Innovation (CPRI) in the College of Pharmacy
- NIH from the National Institute of General Medical Sciences [P20 RR020171]
- National Center for Advancing Translational Science [UL1 TR000117, UL1 TR001998]
Ask authors/readers for more resources
Fluorinated aryl- and heteroaryl-substituted monohydrazones demonstrate excellent broad-spectrum activity against various fungal strains, including clinically relevant Candida auris strains. These compounds exhibit fungicidal activity with low hemolysis and no mammalian cell cytotoxicity, prevent biofilm formation, and do not induce resistance in C. auris over multiple passages.
Fluorinated aryl- and heteroaryl-substituted monohydrazones displayed excellent broad-spectrum activity against various fungal strains, including a panel of clinically relevantCandida aurisstrains relative to a control antifungal agent, voriconazole (VRC). These monohydrazones displayed less hemolysis of murine red blood cells than that of VRC at the same concentrations, possessed fungicidal activity in a time-kill study, and exhibited no mammalian cell cytotoxicity. In addition, these monohydrazones prevented the formation of biofilms that otherwise block antibiotic effectiveness and did not trigger the development of resistance when exposed toC. aurisAR Bank # 0390 over 15 passages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
