Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 68, Pages 15852-15854Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003463
Keywords
N-14 NMR spectroscopy; amyloids; biomolecular NMR spectroscopy; dynamic nuclear polarization; solid-state NMR spectroscopy
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Funding
- EPSRC [EP/M023664/1]
- EPSRC
- EPSRC [EP/M023664/1] Funding Source: UKRI
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Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected N-14 NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.
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