Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 56, Issue 5, Pages 888-891Publisher
SPRINGER
DOI: 10.1007/s10600-020-03176-y
Keywords
Hosta plantaginea; indole alkaloid; inhibition of steroid 5 alpha-reductase activity
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Funding
- National Natural Science Foundation of China [81803843]
- Scientific Research Project of Jiangxi Administration of Traditional Chinese Medicine [2019A002, 2019A018]
- Standard Revision Research Project of National Pharmacopoeia Committee [2018Z090]
- Science and Technology Project of Jiangxi Provincial Department of Education [GJJ180688, GJJ180662]
- Science and Technology Project of Jiangxi Health Commission [20195650, 20195648]
- Scientific Research Project of First-class Discipline of Chinese Materia Medica of Jiangxi University of TCM [JXSYLXK-ZHYAO027, JXSYLXK-ZHYAO032]
- Doctoral Research Initiation Fund Project of Jiangxi University of TCM [2018BSZR010, 2018BSZR007]
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A new indole alkaloid (1), together with eight known indole alkaloid derivatives (2-9), was isolated from Hosta plantaginea for the first time. The structures of compounds 1-9 were elucidated on the basis of comprehensive spectroscopic analyses and references. Compounds 1-9 were evaluated for their inhibition of steroid 5 alpha-reductase activity in vitro. Among them, compounds 1and2 showed important inhibition of steroid 5 alpha-reductase activities.
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