4.3 Review

Synthesis of 2-Azabicyclo[3.3.1]nonanes: Lessons from Synthetic Studies of Macrocyclic Diamine Alkaloids

Journal

CHEMISTRY LETTERS
Volume 50, Issue 1, Pages 96-102

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.200695

Keywords

Alkaloids; Heterocycles; Total synthesis

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This highlight review summarizes the syntheses of 2-azabicyclo-[3.3.1]nonanes, focusing on sarain A and madangamines. Researchers used unique strategies to construct different structures with additional substituents and functional groups in the target molecule.
This highlight review describes the syntheses of 2-azabicyclo-[3.3.1]nonanes, focusing on synthetic studies of the macrocyclic diamine alkaloids, sarain A and madangamines. These alkaloids have a 2-azabicyclo[3.3.1]nonane that is fused with an N-heterocycle. Researchers employed unique strategies to construct different structures with additional substituents and functional groups in the target molecule.

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