4.6 Article

Acid-Acid-Catalyzed Tandem Reactions Driven by an Additive-like Component

Journal

CHEMICAL RECORD
Volume 21, Issue 1, Pages 87-115

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.202000097

Keywords

Acid catalysis; Tandem reaction; Domino reaction; Sequential reaction

Funding

  1. National Natural Science Foundation of China [2171101076, 21872060, 21902054]

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Adding an additive-like component to induce acid-acid-catalyzed tandem reactions can enrich method diversity, simplify operation, and enhance synthetic efficiency.
Acid-catalyzed tandem reactions with auto-tandem catalysis are effective for simplifying organic synthesis. However, some of the reported reactions were established based on the use of well-designed substrate with complex structure. In some cases, owing to the existence of a big gap between each catalytic cycle, it is hard to bind all the individual reaction steps to be a peaceful sequence. To enrich the diversity and also to strengthen the practical usefulness of the methodology developed by auto-tandem catalysis, an additive-like component was added to induce acid-acid-catalyzed tandem reaction. During the reaction, the additive-like component acted either as an activator to increase the reactivity of the starting material or a hided reagent to enable successful transformation of the intermediate. Many novel tandem reactions were established in a one-pot manner with the aid of this strategy. Importantly, this strategy not only allows the use of simple and commercially available chemicals as substrates, but also possesses multiple merits, such as simplifying operation, lowering waste generation and enhancing synthetic efficiency and atom-economy. A summarization of the additive-like component-induced auto-tandem catalysis with an acid catalyst was given in this review, in which many acid-acid-catalyzed tandem reactions were discussed. The reported additive-like components were classified as three types: oxidative type, reductive type and neutral type depending on their mechanisms in assisting the establishment of acid-acid-catalyzed tandem reactions. Many examples were collected and analyzed from the viewpoints of simplifying the synthesis and manifesting their superior and distinct functionalities of the additives. A perspective of this concept was also given at the end of this review.

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