Rhodium(III)-Catalyzed Cross Coupling of Sulfoxonium Ylides and 1,3-Diynes to Produce Naphthol-Indole Derivatives: An AreneorthoC-H Activation/Annulation Cascade

Synthesis of naphthol-indoles starting from easily available 1,3-diynes and sulfoxonium ylides via Rh-III-catalyzed C-H activation/hydroamination cascade process in a one pot manner has been developed. The reaction proceeds through a Rh-III-catalyzed areneorthoC-H activation and silver-catalyzed hydroamination cascade to afford a variety of C2 position functionalized indoles in good yields with broad substrate scope and good functional group tolerance.