Journal
CELLULOSE
Volume 27, Issue 16, Pages 9493-9504Publisher
SPRINGER
DOI: 10.1007/s10570-020-03426-w
Keywords
Temperature-responsive; HPMC-NIPAM aerogels; Drug-loaded aerogel; Drug release
Funding
- National Natural Science Foundation of China [31971605]
- International Joint Research Center for biomass chemistry and materials, Shaanxi international science and technology cooperation base [2018GHJD-19]
- Shandong Key RD Program [2019JZZY010407, 2019JZZY010304]
- Key scientific research plan (Key Laboratory) of Shaanxi Provincial Education Department [17JS016]
- Foundation of Key Laboratory of Pulp and Paper Science and Technology of Ministry of Education/Shandong Province of China [KF201814]
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Temperature-responsive aerogels from hydroxypropyl methylcellulose (HPMC)-grafted N-isopropylacrylamide (NIPAM) were developed for the first time as a novel drug delivery system. The morphology and structure of temperature-responsive HPMC-NIPAM aerogels were characterized with scanning electron microscopy, Fourier-transform infrared, X-ray diffraction, and X-ray photoelectron spectroscopic analyses. Water-soluble 5-fluorouracil was used as a model drug to study drug loading and release. Drug release experiments demonstrated a sustained and controlled release behavior of the HPMC-NIPAM aerogels that were highly dependent on temperature. Meanwhile, the first-order kinetic model, Higuchi model, and Korsmyer-Peppas model were used to fit the sustained-release curve of drug-loaded aerogel revealing a sustained-release mechanism.
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