Journal
CELLULOSE
Volume 27, Issue 17, Pages 10277-10292Publisher
SPRINGER
DOI: 10.1007/s10570-020-03503-0
Keywords
Hydrogel film; Cellulose sulfate; Chitosan hydrochloride; Transdermal delivery; Sustained release
Funding
- Anhui Provincial Program on Key Research and Development Project [202004a06020021]
- National Natural Science Foundation of China [21606002]
- Natural Science Foundation of Anhui Province (CN) [1708085QC64]
- Undergraduate Research Training Programs for Innovation [201910357069, S201910357427]
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Water-soluble polysaccharides of cellulose sulfate (NaCS) and chitosan hydrochloride (CHC) were chosen as the brick materials, while sodium tripolyphosphate (STPP) as a special cement, the NaCS/CHC/STPP hydrogel films loaded with Ibuprofen were fabricated via self-assembly method. The prepared hydrogel films were characterized via SEM, FTIR, TGA and XRD. It manifested that the hydrogel films formed a dense three-dimensional network with a regular shape, and NaCS, CHC and STPP were involved in the formation of polyelectrolyte complex via electrostatic interaction. The Ibuprofen-loaded hydrogel films possessed respective loading and encapsulation efficiency of 43.15 +/- 4.88% and 60.65 +/- 4.68%. It verified that the hydrogel films had favourable sustained release profile during 1440 min test, in which Ibuprofen could penetrate through the skin of mouse in a transdermal drug delivery (TDD) model. The cytotoxicity assays indicated that the hydrogel films had non-toxicity and good biocompatibility. All these results shed light on the hydrogel films prepared could be used to design potential TDD vehicles.
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