Long Non-coding RNAs (lncRNAs), A New Target in Stroke

Stroke has become the most disabling and the second most fatal disease in the world. It has been a top priority to reveal the pathophysiology of stroke at cellular and molecular levels. A large number of long non-coding RNAs (lncRNAs) are identified to be abnormally expressed after stroke. Here, we summarize 35 lncRNAs associated with stroke, and clarify their functions on the prognosis through signal transduction and predictive values as biomarkers. Changes in the expression of these lncRNAs mediate a wide range of pathological processes in stroke, including apoptosis, inflammation, angiogenesis, and autophagy. Based on the exploration of the functions and mechanisms of lncRNAs in stroke, more timely, accurate predictions and more effective, safer treatments for stroke could be developed.

Automated summary

This article summarizes 35 lncRNAs associated with stroke and elucidates their roles and mechanisms in stroke. The study suggests that these lncRNAs regulate pathological processes in stroke and have potential value in predicting prognosis and developing treatments for stroke.