Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 18, Issue 2, Pages 269-278Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-020-00526-2
Keywords
Glucocorticoids; inflammation; immune response
Categories
Funding
- European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Program [648768]
- Agence Nationnale de la Recherche (ANR) [ANR-14-CE14-0009-01]
- ARC foundation [PGA120140200817]
- INSERM
- CNRS
- Aix-Marseille University
- Marseille-Immunopole
- AIRC
- European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie grant [800924]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0009] Funding Source: Agence Nationale de la Recherche (ANR)
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Glucocorticoids are crucial endogenous hormones with anti-inflammatory effects, widely used in clinical practice. However, their complex roles in immune diseases require tight regulation and monitoring.
Glucocorticoids (GCs) are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external environment. Because of their anti-inflammatory effects, synthetic GCs are also extensively used in clinical practice. However, almost all cells in the body are sensitive to GC regulation. As a result, these mediators have pleiotropic effects, which may be undesirable or detrimental to human health. Here, we summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor activation. We also discuss the complex role of GCs in infectious diseases such as sepsis and COVID-19, in which the balance between pathogen elimination and protection against excessive inflammation and immunopathology needs to be tightly regulated. An understanding of the cell type- and context-specific actions of GCs from the molecular to the organismal level would help to optimize their therapeutic use.
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