Journal
CELL CALCIUM
Volume 90, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102253
Keywords
endothelial cells; intracellular calcium; pannexin 1; TNF-alpha; NF-kB; cytokines; transcription; IL-1beta; inflammation
Categories
Funding
- Canadian Institutes of Health Research [MOP142215]
- Natural Sciences and Engineering Research Council [RGPIN-2017-03889]
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A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.
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