Journal
CELL
Volume 183, Issue 1, Pages 16-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2020.08.028
Keywords
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Categories
Funding
- NIH [R01-NS34179, R01-NS100447, R37-NS089323, R01-NS095441, R01-NS/HL37853, R01NS097443, NS094507, NS081179]
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Neurological complications have emerged as a significant cause of morbidity and mortality in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized patients exhibit neurological manifestations ranging from headache and loss of smell, to confusion and disabling strokes. COVID-19 is also anticipated to take a toll on the nervous system in the long term. Here, we will provide a critical appraisal of the potential for neurotropism and mechanisms of neuropathogenesis of SARS-CoV-2 as they relate to the acute and chronic neurological consequences of the infection. Finally, we will examine potential avenues for future research and therapeutic development.
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