Journal
CARBOHYDRATE POLYMERS
Volume 245, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116573
Keywords
Bacterial cellulose; Polydopamine; Silver nanoparticles; Burn wound; Dressing material; Gene expression
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Funding
- Defence Research and Development Organisation (DRDO), Government of India, New Delhi
- Indian Council of Medical Research (ICMR), New Delhi, India
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In the present study, bacterial cellulose (BC) based nanocomposite dressing material was developed for third burn wound management by polydopamine (PD) coated BC with in situ reduction of silver nanoparticles (BC-PDAg). BC-PDAg nanocomposite was characterized to understand the morphological, physical and chemical properties. Antimicrobial activity of BC-PDAg against burn wound specific pathogens were significant. The in vitro cytotoxicity and proliferation studies revealed that BC-PDAg nanocomposite is biocompatible and it sup-ports cell proliferation. Further, in vivo experiments on female albino Wistar rats confirmed that BC-PDAg was effective in wound healing by promoting re-epithelization, and collagen deposition as evidenced by histo-pathological analysis. Moreover, molecular gene expression study has revealed that BC-PDAg promotes healing process by regulating the expression of inflammatory, angiogenesis and growth factor genes. The overall per-formance of BC-PDAg nanocomposite suggests that it could be used as promising skin regenerative tool in modern medicine.
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