Journal
CARBOHYDRATE POLYMERS
Volume 252, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117091
Keywords
Inflammatory bowel diseases; Acetylated inulin; Intestinal drug delivery; Pellets; 5-Aminosalicylic acid; Prebiotics
Categories
Funding
- NO Forschungsund Bildungsges.m.b.H (NFB)
- provincial government of Lower Austria through the Science Call Dissertation Grant [SC16-024]
Ask authors/readers for more resources
This study explored a new preparation technique for pellets made from acetylated inulin to achieve specific intestinal delivery of 5-aminosalicylic acid. The acetylated inulins were insoluble in water with increased hydrophobicity, and showed high drug loading capacity and release rate, offering a promising new strategy for the treatment of Crohn's disease and ulcerative colitis.
This study investigates a novel preparation technique for pellets made from acetylated inulin and their characterization focusing on specific intestinal delivery of 5-aminosalicylic acid. By means of acetylation the hydrophobicity of four native inulins was increased yielding materials with selected degrees of acetylation. The acetylated inulins were insoluble in water, which was confirmed by the log P-values ranging from 1.30 to 1.58. 5Aminosalicylic acid loading capacity of the pellets was up to 60 % and high enough to match the therapeutic range of the anti-inflammatory drug. Depending on the 5-aminosalicylic acid content and the type of acetylated inulin, up to 80 % of the entrapped drug was released within 24 h in intestinal environment under in-vitro conditions. Here we successfully prepared chemically modified and profoundly characterized inulin to provide innovative formulations and to open up a promising new strategy for treatment of Morbus Crohn and ulcerative colitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available