Journal
CANCER LETTERS
Volume 490, Issue -, Pages 186-192Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.07.002
Keywords
Hypoxia; HIF-1; Intestinal tumorigenesis; Colitis; Barrier integrity; Intestinal microbiome
Categories
Funding
- Deutsche Krebshilfe [109160]
- Deutsche Forschungsgemeinschaft [CR 133/21]
Ask authors/readers for more resources
Colorectal cancer ranks among the top three most frequent malignancies in the world. While overall incidence and mortality of colorectal cancer has substantially decreased in recent years, tumor subtypes with poor response rates to standard antiproliferative therapies remain particularly challenging. Hypoxia in the microenvironment of solid tumors is associated with malignant progression, e.g. local invasion, systemic spread and therapy resistance. A detailed molecular understanding of hypoxia's role for the pathobiology of colorectal cancer is a prerequisite to design and evaluate the consequences of interference with hypoxic signaling for the progression of this cancer type. Here, we summarize the current knowledge about the role of hypoxia-inducible factor 1, an essential molecular mediator of the hypoxic response, for colorectal cancer pathogenesis. Special attention is given to intestinal microbiota, gut barrier integrity and chronic inflammation as these are of pivotal importance for intestinal tumorigenesis and noticeably associated with hypoxic signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available