Journal
CANCER INVESTIGATION
Volume 38, Issue 10, Pages 559-564Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2020.1833212
Keywords
Biochemical recurrence; hormonal therapy; prostate cancer; radical prostatectomy; smoking
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Funding
- Smoking Research Foundation, Japan
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We analyzed the association between smoking and oncological outcome after radical prostatectomy with neoadjuvant hormonal therapy. This study included men who had undergone radical prostatectomy with neoadjuvant hormonal therapy between 2003 and 2016. We evaluated the association between clinicopathological factors and smoking status as well as the prognostic significance of smoking status in biochemical recurrence. The patients' backgrounds were comparable between smokers and nonsmokers. Smoking status were identified as significant risk factors of biochemical recurrence. Smoking was a risk factor of biochemical recurrence, suggesting that smoking may promote cancer recurrence after surgical treatment combined with hormonal therapy.
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