Journal
CA-A CANCER JOURNAL FOR CLINICIANS
Volume 71, Issue 1, Pages 78-92Publisher
WILEY
DOI: 10.3322/caac.21638
Keywords
clinical trials; older adults; oncology; patient participation; patient selection; practice patterns
Categories
Funding
- National Institute on Aging [NIA R03AG064377]
- National Cancer Institute [NCI K12CA001727]
- Waisman Innovation Fund
- Circle 1500
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Cancer is a disease of aging, and the number of older patients with cancer is increasing. However, older patients are underrepresented in cancer research and effective strategies to improve their participation in clinical trials are sparse. Studies on barriers and interventions for older adults in cancer trials are limited, highlighting a need for more evidence-based solutions to address this issue.
Cancer is a disease of aging and, as the world's population ages, the number of older persons with cancer is increasing and will make up a growing share of the oncology population in virtually every country. Despite this, older patients remain vastly underrepresented in research that sets the standards for cancer treatments. Consequently, most of what we know about cancer therapeutics is based on clinical trials conducted in younger, healthier patients, and effective strategies to improve clinical trial participation of older adults with cancer remain sparse. For this systematic review, the authors evaluated published studies regarding barriers to participation and interventions to improve participation of older adults in cancer trials. The quality of the available evidence was low and, despite a literature describing multifaceted barriers, only one intervention study aimed to increase enrollment of older adults in trials. The findings starkly amplify the paucity of evidence-based, effective strategies to improve participation of this underrepresented population in cancer trials. Within these limitations, the authors provide their opinion on how the current cancer research infrastructure must be modified to accommodate the needs of older patients. Several underused solutions are offered to expand clinical trials to include older adults with cancer. However, as currently constructed, these recommendations alone will not solve the evidence gap in geriatric oncology, and efforts are needed to meet older and frail adults where they are by expanding clinical trials designed specifically for this population and leveraging real-world data.
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