Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 177, Issue 22, Pages 5031-5045Publisher
WILEY
DOI: 10.1111/bph.15246
Keywords
3-mercaptopyruvate sulfurtransferase; hydrogen sulfide; nitric oxide; polysulfides; S-nitrosylation; S-sulfuration
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Funding
- Strategic Research Program for Brain Sciences from the Japan Agency for Medical Research and Development, AMED [JP20dm0107085]
- KAKENHI [17K08331]
- Grants-in-Aid for Scientific Research [17K08331] Funding Source: KAKEN
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Hydrogen sulfide (H2S) together with polysulfides (H2Sn,n > 2) are signalling molecules like NO with various physiological roles including regulation of neuronal transmission, vascular tone, inflammation and oxygen sensing. H2S and H(2)S(n)diffuse to the target proteins for S-sulfurating their cysteine residues that induces the conformational changes to alter the activity. On the other hand, 3-mercaptopyruvate sulfurtransferase transfers sulfur from a substrate 3-mercaptopyruvate to the cysteine residues of acceptor proteins. A similar mechanism has also been identified in S-nitrosylation. S-sulfuration and S-nitrosylation by enzymes proceed only inside the cell, while reactions induced by H2S, H(2)S(n)and NO even extend to the surrounding cells. Disturbance of signalling by these molecules as well as S-sulfuration and S-nitrosylation causes many nervous system diseases. This review focuses on the signalling by H2S and H(2)S(n)with S-sulfuration comparing to that of NO with S-nitrosylation and discusses on their roles in physiology and pathophysiology.
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