Journal
BRITISH JOURNAL OF OPHTHALMOLOGY
Volume 105, Issue 11, Pages 1520-1524Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bjophthalmol-2020-317309
Keywords
Infection; Imaging
Categories
Funding
- Hyderabad Eye Research Foundation
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This study utilized adaptive optics scanning laser ophthalmoscopy to reveal a reduced number of foveal cones in eyes with resolved endophthalmitis, even in the absence of detectable gross structural changes. The emerging technology of AO-SLO allows for retinal cell biology study at the cellular level, providing insights into the pathophysiology of various retinal diseases.
Aim To report the foveal cone count in eyes with resolved endophthalmitis vis-a-vis normal fellow eyes using an indigenous adaptive optics scanning laser ophthalmoscopy (AO-SLO). Methods In a prospective cross-sectional comparative pilot study, we recruited patients with resolved endophthalmitis in one eye (study eye) and a normal fellow eye (control eye). Collected data included measurement of the best-corrected visual acuity (BCVA), spectral-domain optical coherence tomography (OCT) imaging and AO-SLO imaging and cone counting at the fovea in both eyes. Results The study included 12 eyes of 6 patients. The mean age was 51.66 +/- 11.97 years (median 56 years). BCVA in all control eyes was 20/20 (logarithm of the minimum angle of resolution (LogMAR) 0), and in the study, eyes was 0.21 +/- 0.13 (median 0.19, Snellen 20/30; p=0.001; 95% CI -0.39 to -0.09). The follow-up was 18.66 +/- 12.32 (median 20 months). The cone count at the fovea in the control eye was 4356.33 +/- 1993.93 (median 4498), and in the study eye, it was 2357.16 +/- 1541.17 (median 2187.5; p=0.03; 95% CI -3556 to -1082). Conclusions Eyes with resolved endophthalmitis with near-normal vision have reduced number of foveal cones even in absence of OCT-detected gross structural changes. Translational Relevance The current work describes the application of cellular-level imaging technique called adaptive optics scanning laser ophthalmoscopy (AO-SLO) to the clinical condition of resolved endophthalmitis. The study of retinal cell biology at the cellular level is possible using the emerging technology of AO-SLO. This new investigative modality that has the potential to image the retina at the cellular level until the photoreceptors is more likely to unravel the pathophysiology of a variety of retinal diseases.
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