Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 193, Issue 2, Pages 231-244Publisher
WILEY
DOI: 10.1111/bjh.17185
Keywords
molecular MRD; AML; NPM1mutations
Categories
Funding
- Blood Cancer UK
- Cancer Research UK
- National Institute of Health Research (NIHR) Biomedical Research Centre at Guy's Hospital
- NIHR programme grant [RP-PG-0108-10093]
- Cancer Research UK [ISRCTN55675535]
- Cardiff University
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Recent years have seen significant advances in the use of molecular diagnostic and monitoring techniques for patients with acute myeloid leukaemia (AML), coupled with the development of new therapeutic agents. This has led to potential improvements in treatment algorithms. The article highlights the importance of molecular monitoring in refining clinical decision-making and personalizing treatment for AML patients, with practical recommendations provided for cases where evidence is lacking or conflicting. Additionally, important technical considerations for clinicians to safely utilize these technologies are reviewed as they become more widely implemented.
In recent years there have been major advances in the use of molecular diagnostic and monitoring techniques for patients with acute myeloid leukaemia (AML). Coupled with the simultaneous explosion of new therapeutic agents, this has sown the seeds for significant improvements to treatment algorithms. Here we show, using a selection of real-life examples, how molecular monitoring can be used to refine clinical decision-making and to personalise treatment in patients with AML with nucleophosmin (NPM1) mutations, core binding factor translocations and other fusion genes. For each case we review the established evidence base and provide practical recommendations where evidence is lacking or conflicting. Finally, we review important technical considerations that clinicians should be aware of in order to safely exploit these technologies as they undergo widespread implementation.
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