Journal
BRITISH JOURNAL OF CANCER
Volume 123, Issue 9, Pages 1353-1355Publisher
SPRINGERNATURE
DOI: 10.1038/s41416-020-1020-6
Keywords
-
Categories
Funding
- Cancer Research UK [A203904, A20256, A27989]
- Medical Research Council UK [MR/P013414/1]
Ask authors/readers for more resources
Recent studies have highlighted a major role for cancer-associated fibroblasts (CAFs) in promoting immunotherapy resistance by excluding T cells from tumours. Recently, we showed that CAFs can be effectively targeted by inhibiting the enzyme NOX4; this 'normalises' CAFs and overcomes immunotherapy resistance. Here we discuss our study and other strategies for CAF targeting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
