Journal
BRAZILIAN JOURNAL OF MICROBIOLOGY
Volume 52, Issue 1, Pages 145-153Publisher
SPRINGER
DOI: 10.1007/s42770-020-00362-6
Keywords
Antifungal treatment; Felis catus; Serology; Sporothichosis; Sporothrix brasiliensis; Zoonoses
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Funding
- National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq)
- Rio de Janeiro Research Foundation (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ) [E-26/103.198/2011, E-26/010.001882/2014]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
- PROEX-MEC
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The study suggests that sporotrichosis zoonotic transmission by cats has reached a high level of local transmission in Rio de Janeiro, Brazil. The SsCBF ELISA test is found to be valuable for predicting therapeutic responses in feline sporotrichosis.
Sporotrichosis zoonotic transmission by cats has obtained hyperendemic magnitude in Rio de Janeiro, Brazil.Atypical cases, relapses, and reinfections as well as reduced diagnostic sensitivity of conventional methods have been reported. Previously, the anti-SsCBF enzyme-linked immunosorbent assay (ELISA) test was shown to be useful as a diagnostic tool for human sporotrichosis. Effective diagnosis and treatment are critical to interrupt the chain of transmission of this major pathogen in Brazilian Public Health. To evaluate its applicability for feline sporotrichosis diagnosis and/or therapeutic follow-up, 15 domestic cats from Rio de Janeiro were clinically and laboratory monitored by cytopathology, culture,Sporothrixgenotyping, and anti-SsCBF IgG levels. Subsequently, animals were divided into satisfactory and non-satisfactory therapeutic responders. Averages of antibody serum levels obtained for diagnosis (first consultation) compared with the levels found after follow-up (last consultation) were significantly different in both groups (p = 0.0002 andp = 0.038, respectively). We conclude that the SsCBF ELISA test can predict feline sporotrichosis therapeutic responses even for animals with distinct clinical evolutions.
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