Journal
BONE MARROW TRANSPLANTATION
Volume 56, Issue 2, Pages 457-460Publisher
SPRINGERNATURE
DOI: 10.1038/s41409-020-01038-3
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Funding
- Rigshospitalet's Research Funds (Denmark)
- Danish Childhood Cancer Foundation
- Danish Cancer Society
- Dagmar Marshall's Foundation (Denmark)
- Hartmann Brothers' Foundation (Denmark)
- Danish Cancer Research Foundation
- Finnish Cancer Society
- Finnish Foundation of Paediatric Research
- Helsinki University Research Foundation (Finland)
- Swedish Childhood Cancer Foundation
- Swedish Research Council
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Among survivors of paediatric allogeneic hematopoietic stem cell transplantation (HSCT), lower Lean Body Mass Index and Skeletal Muscle Mass Index, as well as higher android/gynoid (AG) fat ratio, were observed. Low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was related to lower testosterone levels. The combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, emphasizing the importance of long-term monitoring in these patients.
Changes in body composition related to metabolic syndrome are frequent among survivors of haematopoietic stem cell transplantation (HSCT), but insights into predisposing factors are incomplete, and it is unknown to what degree these changes persist at long term. We cross-sectionally investigated body composition by dual-energy X-ray absorptiometry in 98 male survivors of paediatric allogeneic HSCT. Median (range) age at follow-up was 28.1 (18.5-47.0) years and median (range) time from transplant was 18.3 (7.7-34.6) years. Lean Body Mass Index and Skeletal Muscle Mass Index were lower in patients compared to the reference population (mean (SD) standard deviation score (SDS) -1.29 (0.99), p < 0.001 and -1.20 (1.03), p < 0.001). Fat Mass Index was comparable to the reference population, but android/gynoid (AG) fat ratio SDS was higher (mean (SD) 0.46 (1.28), p < 0.001). These changes were found in patients treated with total body irradiation (TBI) as well as non-TBI regimens, although most pronounced in the former. Further, low lean mass was associated with chronic graft-versus-host disease, while high AG ratio was associated with lower testosterone levels. Since the combination of low lean mass and high AG ratio increases the risk of cardio-metabolic disease, these health issues should be monitored at long-term clinical follow-up after paediatric HSCT.
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