Journal
BMC CANCER
Volume 20, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12885-020-07512-x
Keywords
Colorectal cancer; microRNA-203; Biomarker; Prognosis
Categories
Funding
- National Natural Science Foundation of China [82003219]
- Advance Research Program for Young and Middle-aged Backbone of Suzhou Science & Technology Town Hospital [2019Y04]
- Suzhou Introduction Project of Clinical Medical Expert Group [SZYJTD201804]
- Suzhou Science and Technology Development Project [SYS2019059]
- Jiangsu Medical Innovation Team [CXDT-37]
- Scientific Research Program for Young Talents of China National Nuclear Corporation [51003]
- Pre-research program of the Second Affiliated Hospital of Soochow University [SDFEYBS1701]
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BackgroundIncreasing studies indicated that microRNA-203 (miR-203) may play an important part in the prognosis of CRC. Nevertheless, the prognostic and influential mechanism of miR-203 expression in CRC remains to be inconclusive. Accordingly, we conducted the current study to investigate the biomarker performance of miR-203 in CRC.MethodsIn the present study, we conducted an evidence synthesis of the published literatures to identify the prognostic roles of miR-203 in patients with CRC. Moreover, several bioinformatics methods were applied for exploring the biomarker roles of miR-203.ResultsIt was demonstrated that elevated miR-203 expression was clearly related to worse overall survival (HR: 1.55, 95% CI: 1.07-2.24, P=0.021) for CRC. The gene Ontology (GO) analysis indicated that miR-203 targets were primarily involved in a series of GO items closely associated with the molecular pathogenesis of CRC. The pathway analysis exhibited the potential signal pathways of miR-203 involved in CRC including pathways in cancer, wnt pathway, prolactin signaling pathway, proteoglycans in cancer, FoxO pathway, focal adhesion and Ras pathway. By constructing a protein-protein interaction (PPI) network of the targets of miR-203, ten crucial proteins and a significant network module were retrieved and found to serve important roles in the molecular pathogenesis of CRC.ConclusionsOur results indicated that miR-203 may function as a promising biomarker to monitor CRC survival outcomes and progression. Notably, large-scale prospective cohort studies and biological experiments are required to confirm our conclusions.
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