Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 68, Issue 6, Pages 1192-1201Publisher
WILEY
DOI: 10.1002/bab.2041
Keywords
10-hydroxycamptothecine; electrochemical detection; polyaniline; MWCNTs
Funding
- National Natural Science Foundation of China [81773480, 81973097, 81673229, 81703269]
- Major Weak Subjects in Pudong New Area [PWZbr2017-02]
- Shanghai Pudong Hospital Talent Project [PX201604]
- Natural Science Foundation of Heilongjiang Province [QC2018120]
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2017173]
- Fundamental Research Funds for the Universities of Heilongjiang Province [2017-KYYWF-0648]
- Administration of Science & Technology Foundation of Mudanjiang [Z2016s0072]
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The study utilized a one-step electro-deposition method to prepare PANI and f-MWCNTs films on glass carbon electrodes for an electrochemical sensor to detect 10-HCPT. The f-MWCNTs were modified through ultrasound processing for better dissolution in water and attachment of new functional groups. The resulting sensor showed a wide linear range and low detection limit due to its large special surface area and good conductivity.
In our work, one-step electro-deposition method was adopted to produce polyaniline (PANI) and functional multiwalled carbon nanotubes (f-MWCNTs) films on glass carbon electrodes, and the modified electrodes were applied as an electrochemical sensor for determination of 10-hydroxycamptothecine (10-HCPT). The f-MWCNTs were handled by ultrasound processing in concentrated oxidizing acid solution, which can obtain a wonderful dissolution in water and attach new functional groups, such as -COOH and -OH. Then, aniline monomer could polymerize on the surface easily. The surface characterization was investigated using various techniques including scanning electron microscope, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction, and electro-catalytic properties were characterized by cyclic voltammetry and electrochemical impedance spectroscopy. Under optimal conditions, the resulting of PANI/f-MWCNTs sensor showed a wide linear range (3 x 10(-9)to 7 x 10(-7)mol L-1) and a low detection limit (1x10(-9)mol L-1), which is attributing to its large special surface area and good conductivity. Moreover, the modified electrodes are convenient to fabricate, which can be used to detect 10-HCPT in urine samples successfully.
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