Recent developments in the use of peroxygenases - Exploring their high potential in selective oxyfunctionalisations

Peroxygenases are an emerging new class of enzymes allowing selective oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 monooxygenases. Herein, we focused on recent de-velopments from organic synthesis, molecular biotechnology and reaction engineering viewpoints that are devoted to bring these enzymes in industrial applications. This covers natural diversity from different sources, protein engineering strategies for expression, substrate scope, activity and selectivity, stabilisation of enzymes via immobilisation, and the use of peroxygenases in low water media. We believe that peroxygenases have much to offer for selective oxyfunctionalisations and we have much to study to explore the full potential of these versatile biocatalysts in organic synthesis.

Automated summary

Peroxygenases are a new class of enzymes that allow selective oxyfunctionalisation reactions without the need for a cofactor, different from well-known P450 monooxygenases. Recent developments in organic synthesis, molecular biotechnology, and reaction engineering have focused on utilizing these enzymes in industrial applications. There is great potential for peroxygenases in selective oxyfunctionalisations and further studies are required to explore their full capabilities in organic synthesis.