4.8 Article

Advanced lab-on-a-chip to detect viruses - Current challenges and future perspectives

Journal

BIOSENSORS & BIOELECTRONICS
Volume 163, Issue -, Pages -

Publisher

ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112291

Keywords

Virus outbreak; Microfluidic chip; Lab on a chip; Virus detection

Funding

  1. National Program on Key Research Project of China [SQ2019YFE010999]
  2. European Union's Horizon 2020 Research and Innovation Program [861917-SAFFI]
  3. National Key R&D Program of China [2018YFF01012100]
  4. Fundamental Research Funds for the Zhejiang Provincial Universities [2-2050205-19-007]
  5. Open Research Project of the State Key Laboratory of Industrial Control Technology, Zhejiang University, China

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Massive viral outbreaks draw attention to viruses that have not been thoroughly studied or understood. In recent decades, microfluidic chips, known as lab-on-a-chip, appears as a promising tool for the detection of viruses. Here, we review the development of microfluidic chips that could be used in response to viral detection, specifically for viruses involved in more recent outbreaks. The advantages as well as the disadvantages of microfluidic systems are discussed and analyzed. We also propose ideas for future development of these microfluidic chips and we expect this advanced technology to be used in the future for viral outbreaks.

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