Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 30, Issue 20, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127476
Keywords
Dihydronaphtho [2,1-b] furan; DBU; Anti-proliferative; Anti-cancer; Apoptosis
Categories
Funding
- SERB, India [PDF/2017/001211, PDF/2017/001782]
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A series of 1,2-dihydronaphtho [2,1-b]furan derivatives were synthesized by cyclizing 1-(aryl/alkyl(arylthio) methyl)-naphthalen-2-ol and pyridinium bromides in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in very good yield. The synthesized compounds were evaluated for their anti-proliferative potential against human triple negative MDA-MB-468 and MCF-7 breast cancer cells and non-cancerous WI-38 cells (lung fibroblast cell) using MTT experiments. Among 21 synthesized compounds, three compounds (3a, 3b and 3 s) showed promising anti-cancer potential and compound 3b was found to have best anti-proliferative activities based on the results of several biochemical and microscopic experiments.
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