Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 28, Issue 18, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2020.115556
Keywords
Endocytosis; Drug delivery; Liposomes; Bacteriophages; Viral vectors
Funding
- National Centre for Research and Development [POIR.04.01.04-00-0050/15]
- National Science Centre in Poland [UMO-2017/25/N/NZ7/02165, UMO-2012/05/E/NZ6/03314, UMO-2015/19/N/NZ4/03609]
- Wroclaw Centre of Biotechnology, program The Leading National Research Centre (KNOW)
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Drug delivery vectors are widely applied to increase drug efficacy while reducing the side effects and potential toxicity of a drug. They allow for patient-tailored therapy, dose titration, and therapeutic drug monitoring. A major part of drug delivery systems makes use of large nanocarriers: liposomes or virus-like particles (VLPs). These systems allow for a relatively large amount of cargo with good stability of vectors, and they offer multiple options for targeting vectors in vivo. Here we discuss endocytic pathways that are available for drug delivery by large nanocarriers. We focus on molecular aspects of the process, including an overview of potential molecular targets for studies of drug delivery vectors and for future solutions allowing targeted drug delivery.
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