Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 130, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110623
Keywords
Cancer stem cells (CSCs); Hypoxia inducible factors (HIFs); Tumor resistance; HIF inhibitors
Funding
- National Natural Science Foundation of China [U1608281]
- National Natural Science Foundation of China (NSFC) [81972794, 81902708]
- Key R&D Guidance Plan Projects in Liaoning Province [2019JH8/10300011]
- Shenyang ST Projects [19-109-4-09]
- Liaoning provincial department of education scientific research project [QN2019034]
- National Natural Science Foundation of Liaoning [U1608281]
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Drug resistance is a major obstacle in the treatment of tumors, which easily lead to relapse or poor prognosis. Cancer stem cells (CSCs) are regarded as one of the important targets that mediate tumor resistance. Increasing evidence shows that the tumor hypoxia microenvironment is closely related to the resistance of CSCs to chemotherapy and radiotherapy. In this review, we intend to review the articles that have described how the hypoxic microenvironment affects CSC stemness and mediates tumor resistance and provide new directions and methods in the clinical treatment of tumors. Here, we also discuss the feasibility and development prospects of using hypoxia-inducible factors (HIFs) that regulate the hypoxic microenvironment of tumors as targeted agents to treat tumors, as well as to reduce or even reverse the resistance of tumors to chemotherapy and radiotherapy.
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