Journal
BIOINORGANIC CHEMISTRY AND APPLICATIONS
Volume 2020, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2020/8852470
Keywords
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Funding
- Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2015, 2018)
- Guangzhou Science and Technology Program [201904010381]
- Pearl River Scholar Foundation of Guangdong Industry Polytechnic [RC2015-001]
- Scientific and Technological Innovation Project of College Students in Guangdong Province [pdjh2019b0690]
- Youth Innovation Talent Project of Guangdong Province [2018GkQNCX033]
- Characteristic Innovation Project of Guangdong Province [2017GKTSCX005]
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Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between alpha-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.
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