Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1867, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165992
Keywords
Mitochondrial permeability transition pore; Post-translational modifications; Systematic review; Cardiac physiology; Cardiac physiopathology; Cardiac disease; Heart failure; Ischemia/reperfusion injury; Obesity cardiomyopathy; Diabetic cardiomyopathy
Funding
- Consejo Nacional de Ciencia y Tecnologia, Mexico (CONACYT) [256577, 258197]
- Fronteras de la Ciencia Grant [0682]
- Ciencia Basica [A1-S-43883]
- CONACYT (Ciencia Basica)
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PTMs play a crucial role in regulating mPTP in the pathophysiology of cardiac diseases, potentially altering mitochondrial function. Further investigation into this regulatory mechanism may lead to the discovery of new therapeutic targets and treatment approaches.
The mitochondrial permeability transition pore (mPTP) opening is involved in the pathophysiology of multiple cardiac diseases, such as ischemia/reperfusion injury and heart failure. A growing number of evidence provided by proteomic screening techniques has demonstrated the role of post-translational modifications (PTMs) in several key components of the pore in response to changes in the extra/intracellular environment and bioenergetic demand. This could lead to a fine, complex regulatory mechanism that, under pathological conditions, can shift the state of mitochondrial functions and, thus, the cell's fate. Understanding the complex relationship between these PTMs is still under investigation and can provide new, promising therapeutic targets and treatment approaches. This review, using a systematic review of the literature, presents the current knowledge on PTMs of the mPTP and their role in health and cardiac disease.
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