Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1862, Issue 9, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2020.183356
Keywords
Solution NMR spectroscopy; Structural biology; Integral membrane proteins; Protein expression; Isotope labeling; Membrane mimetics
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Funding
- NSERC (Natural Sciences and Engineering Research Council of Canada) [RGPIN-2015-06664]
- CIHR (Canadian Institutes of Health Research) Phase 2 Clinician Scientist Salary Award
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Integral membrane proteins (IMPs) perform unique and indispensable functions in the cell, making them attractive targets for fundamental research and drug discovery. Developments in protein production, isotope labeling, sample preparation, and pulse sequences have extended the utility of solution NMR spectroscopy for studying IMPs with multiple transmembrane segments. Here we review some recent applications of solution NMR for studying structure, dynamics, and interactions of polytopic IMPs, emphasizing strategies used to overcome common technical challenges.
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