Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1862, Issue 9, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbamem.2020.183298
Keywords
Blood-brain barrier; Drug delivery system; Tight junction; Paracellular route; Claudin-5
Categories
Funding
- Science Foundation Ireland (SFI) [12/YI/B2614, 11/PI/1080]
- Health Research Board of Ireland (HRB)
- BrightFocus Foundation
- SFI [16/RC/3948]
- Japan Society for the Promotion of Science [17J03990]
- European Regional Development fund
- Grants-in-Aid for Scientific Research [17J03990] Funding Source: KAKEN
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The blood-brain barrier (BBB) is the one of the most robust physical barriers in the body, comprised of tight junction (TJ) proteins in brain microvascular endothelial cells. The need for drugs to treat central nervous systems diseases is ever increasing, however the presence of the BBB significantly hampers the uptake of drugs into the brain. To overcome or circumvent the barrier, many kinds of techniques are being developed. Modulating the paracellular route by disruption of the TJ complex has been proposed as a potential drug delivery system to treat brain diseases, however, it has several limitations and is still in a developmental stage. However, recent significant advance in medical equipment /tools such as targeted ultra-sound technologies may resolve these limitations. In this review, we introduce recent advances in site- or molecular size-selective BBB disruption/modulation technologies and we include details on pharmacological inhibitory molecules against intercellular TJ proteins to modulate the BBB.
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