Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 533, Issue 4, Pages 679-684Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.10.037
Keywords
Tumor-associated macrophages; Cancer metastasis; IL-6; PRMT1; EZH2; Post-translational modifications
Categories
Funding
- National Natural Science Foundation of China [81802637]
- Natural Science Foundation of Jiangsu Province [BK20190989]
- China Postdoctoral Science Foundation [2019M651971]
- Natural Science Foundation of Jiangsu Province Universities [18KJB310016]
- Research Foundation of Xuzhou Medical University [D2018020]
- Xuzhou City Science and Technology Plan Project [KC19065]
- Jiangsu Provincial Key Medical Discipline, the Project of Invigorating Health Care through Science, Technology and Education [ZDXKA2016014]
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Tumor-associated macrophages (TAMs) are important monocytes in the breast cancer microenvironment. They facilitate the distant metastasis of breast cancer. However, the detailed mechanisms of TAMderived cancer metastasis have not been clearly elucidated. Here, we demonstrate that PRMT1 is essential for TAM-mediated breast cancer cell migration and metastasis. TAMs increase EZH2 stability by stimulating PRMT1-mediated meR342-EZH2 formation through the secretion of interleukin-6 (IL-6) cytokine. Moreover, high expression levels of TAMs are positively correlated with PRMT1, meR342-EZH2, and EZH2 expression in breast cancer patients. Our study presents a novel mechanism of TAM-induced breast cancer metastasis via the IL-6-PRMT1-meR342-EZH2 axis. (C) 2020 Elsevier Inc. All rights reserved.
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