Journal
BEHAVIORAL NEUROSCIENCE
Volume 135, Issue 3, Pages 326-335Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/bne0000418
Keywords
chronic social defeat stress; mouse model; behavioral deficits; modifications
Categories
Funding
- National Natural Science Foundation of China [81771193]
Ask authors/readers for more resources
Stress is the main cause of mood disorders, with individuals responding differently to stress. The CSDS mouse model can mimic individual differences in stress responses in humans and has been used to study depression and anxiety. Research has focused on summarizing behavioral deficits of the CSDS mouse model and developing modified versions for future studies and applications.
Stress is the main cause of mood disorders such as depression and posttraumatic stress disorder. Individuals respond to stress differently, as some develop depressive symptoms, whereas others successfully cope with adversity, but it remains unclear what makes some particularly vulnerable to stress. The chronic social defeat stress (CSDS) mouse model, an ethologically valid rodent model that exhibits long-term physiological and behavioral phenotypes similar to depression and anxiety, can imitate individual differences in stress responses in humans. In this review, we not only summarize various behavioral deficits of the CSDS mouse model that were reported since its establishment but also concentrate on modified CSDS mouse models that have been developed in recent years, aiming at providing useful information for future research and application of this model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available