Journal
ARCHIVES OF VIROLOGY
Volume 165, Issue 12, Pages 2953-2959Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-020-04832-y
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Funding
- Swedish Research Council Formas [2018-00591, 2015-00430, 2019-01316]
- Swedish Foundation for Strategic Research (SSF), through a Future Research Leaders Grant [FFL5]
- Helge Ax:son Johnsons foundation
- Science for Life Laboratory
- Knut and Alice Wallenberg Foundation
- National Genomics Infrastructure - Swedish Research Council
- Uppsala Multidisciplinary Center for Advanced Computational Science
- Formas [2015-00430, 2018-00591] Funding Source: Formas
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Chrysanthemum virus B encodes a multifunctional p12 protein that acts as a transcriptional activator in the nucleus and as a suppressor of RNA silencing in the cytoplasm. Here, we investigated the impact of p12 on accumulation of major classes of small RNAs (sRNAs). The results show dramatic changes in the sRNA profiles characterised by an overall reduction in sRNA accumulation, changes in the pattern of size distribution of canonical siRNAs and in the ratio between sense and antisense strands, lower abundance of siRNAs with a U residue at the 5 '-terminus, and changes in the expression of certain miRNAs, most of which were downregulated.
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