Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 64, Issue 11, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01221-20
Keywords
Acinetobacter; siderophore
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Cefiderocol is a siderophore cephalosporin active against many multidrugresistant (MDR) Gram-negative pathogens. We examined the resistance mechanisms in 12 Acinetobacter baumannii strains with cefiderocol MICs ranging from <= 0.03 to >32 mu g/ml. Cefiderocol resistance could not be explained by beta-lactamase activity. Cefiderocol resistance was associated with reduced expression of the siderophore receptor gene pirA. Mutations involving PBP3 may have contributed to resistance in one strain. Additional studies are needed to assess the role of other siderophore receptors.
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